Non-alcoholic steatotic hepatitis or NAFLD (non-alcoholic fatty liver disease) is part of a spectrum of liver diseases that range from a simple isolated steatosis (“fatty liver”) or NAFL (non-alcoholic fatty liver) to NASH (non-alcoholic steatohepatitis). NAFL is characterized by the accumulation of triglycerides in the liver. It is a risk condition for NASH, which strongly increases the risk of cirrhosis and hepatocellular carcinoma, and has a very low survival rate. The close ties between these diseases and metabolic disorders, obesity, insulin resistance, dyslipidemia, type 2 diabetes and arterial hypertension, have led the international scientific community to recently coin the term “metabolic-associated fatty liver disease” or MAFLD.
According to the World Gastroenterology Organisation, the prevalence of NAFL and NASH has doubled in the last 20 years. Today, NAFL affects 20% to 26% of the population in Europe and 20% to 46% of the population in the United States. To date, no therapeutic or preventive treatment has proven its efficacy and is available to treat these hepatic disorders.
-World Gastroenterology Organisation Global Guidelines,
-Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis, 2012 ;
-Younossi et al. Hepatology, 2016 ; Williams et al., Gastroenterology, 2011